Zhiliang Cheng, Ph.D.
Research Associate Professor
Department of Bioengineering, University of
Pennsylvania, Philadelphia, PA 19104
zcheng@seas.upenn.edu
Tel: 215-746-5887
Office: 117 Hayden Hall
RESEARCH
SUMMARY
My current research in University of Pennsylvania
has been focused on the development of novel imaging agents and drug delivery
systems. Specifically, I am developing new formulations of multifunctional
nanoparticles including liposomes, polymersomes and
micelles, for in vivo imaging and targeted drug delivery to facilitate the
realization of individual therapy. The long-term goal of my research is to
develop new nanotechnology for better understanding of biology, early diagnosis
of disease, monitoring therapy response, and for guiding drug
discovery/development. Once implemented, these technologies will provide more
options to the clinician in providing personalized patient care, at an earlier
time point, than currently available methods.
RESEARCH PROJECTS
1. Nanoparticle-based contrast agents
including fluorescence, photoacoustic (PA) and magnetic resonance (MR)
2. Multifunctional nanoparticles for precise
drug delivery including small molecules, peptides, and large biomolecules
3. Advanced technology for low back
pain treatment
4. Advanced technology for joint
disease treatment
SELECTED
PUBLICATIONS
Bian
Jang, Ahmad Amirshaghaghi, Jeongmoon
Choi, Joann Miller, David Issadore, Theresa M. Busch,
Zhiliang Cheng*, and Andrew Tsourkas*,
Enhanced accumulation and penetration of magnetic nanoclusters in tumors using
an 8−magnet Halbach array leads to improved cancer treatment, ACS Nano.
Accepted.
2024
Noah Weingarten, Amit Iyengar, Jessica
Dominic, Danika Meldrum, Andrew Belec, Sara Guevara-Plunkett, Rachel Wilson, Joyce Ho,
Mrinal Patel, Chaitanya Karimanasseri, Ahmad Amirshaghaghi,
Daphne Nie, Benjamin W. Lee, Deborah M Eaton, Kenneth B. Margulies, Zhiliang
Cheng, Andrew Tsourkas, Pavan Atluri*, Micellized
Naringenin Augments Hemodynamics After Myocardial Infarction By Suppressing Tubulin Detyrosination, Applied Sciences, 2024, 14, 11936. (Abstract)
Yiran Tian, Nicole Carrillo-Malani, Kailin
Feng, Joann Miller, Theresa M. Busch, Karthik M. Sundaram, Zhiliang Cheng,
Ahmad Amirshaghaghi*, Andrew Tsourkas*,
Theranostic Phthalocyanine and Naphthalocyanine Nanoparticles for Photoacoustic Imaging
and Photothermal Therapy of Tumors, Nanotheranostics 2024, 8, 100-111. (Abstract)
Qiushi Liang, Zhiliang Cheng*, Ling Qin*
Advanced nanoparticles in osteoarthritis treatment, Biomaterials Translational. 2024, 5, 95-113. (Abstract)
2023
, , , , *, *, Hemin-Coated
Nanoparticles as Drug Delivery Vehicles for Chemotherapeutic Agents in Cancer
Therapy, ACS Applied Nano
Materials. 2023, 6, 22, 20678 (Abstract)
Ahmad Amirshaghaghi, Wen-Chi
Chang, Bonirath Chhay, Ariane R. Bartolomeu, Margie
L. Clapper, Zhiliang Cheng, Andrew Tsourkas*, Phthalocyanine-Blue Nanoparticles for the
Direct Visualization of Tumors with White Light Illumination, ACS Applied Materials
& Interfaces, 2023, 15, 33373 (Abstract)
2022
Tao Gui, Yulong Wei, Lijun Luo, Jun Li, Leilei Zhong, Lutian Yao, Frank
Beier, Charles L. Nelson, Andrew Tsourkas, X. Sherry
Liu, Motomi Enomoto-Iwamoto,
Feifan Yu, Zhiliang Cheng, Ling Qin.* Activating EGFR Signaling Attenuates Osteoarthritis Development
Following Loading Injury in Mice, Journal of Bone and Mineral Research. 2022, 37, 2498.
(Abstract)
Tao Gui,a
Lijun Luo,a Bonirath
Chhay, Leilei Zhong, Yulong Wei, Lutian
Yao, Wei Yu, Jun Li, Charles L. Nelson, Andrew Tsourkas,
Ling Qin,* and Zhiliang Cheng.*
Superoxide dismutase-loaded porous polymersomes as
highly efficient antioxidant nanoparticles targeting synovium for
osteoarthritis therapy. Biomaterials. 2022, 283, 121437. (a:
co-first author) (Abstract)
2021
Peter J. Altshuler, Alexis R. Schiazza, Lijun Luo, Mark R. Helmers, Bonirath Chhay, Jason J. Han, Robin Hu, D. Alan Herbst,
Andrew Tsourkas, Zhiliang Cheng,* Pavan Atluri.* Superoxide Dismutase-Loaded
Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect
Against Chronic Adverse Ventricular Remodeling. Advanced
Therapeutics.
2021, 4(6), 2100036. (Abstract)
Yulong Wei, Lesan Yan, Lijun Luo, Tao Gui, Biang Jang, Ahmad Amirshaghaghi, Tianyan
You, Andrew Tsourkas, Ling Qin,*
Zhiliang Cheng.* Phospholipase A2 inhibitor-loaded
micellar nanoparticles attenuate inflammation
and mitigate osteoarthritis progression. Science Advances. 2021, 7,
eabe6374. (Full
Text) (News
Release)
Yulong Wei, Lijun
Luo, Tao Gui, Feifan Yu, Lesan
Yan, Lutian Yao, Leilei
Zhong, Wei Yu, Biao Han, Jay M. Patel, Jessica F. Liu, Frank Beier, Lawrence
Scott Levin, Charles Nelson, Zengwu Shao, Lin Han,
Robert L. Mauck, Andrew Tsourkas, Jaimo
Ahn, Zhiliang Cheng,* and Ling Qin.* Targeting cartilage EGFR pathway for osteoarthritis treatment. Science Translational Medicine. 2021, 13, eabb3946. (Abstract)
(Highlights)
Xiaoya Bi,
Libo Li, Xiaohong Liu,
Lijun Luo, Zhiliang Cheng, Jinying Sun, Zhibin Cai, Jinming Liu, Tianyan You. Inner filter effect-modulated ratiometric fluorescence aptasensor
based on competition strategy for zearalenone detection in cereal crops: Using
mitoxantrone as quencher of CdTe QDs@SiO2. Food Chemistry.
2021, 349, 1-8. (Abstract)
2020
Clare W. Teng,
Ahmad Amirshaghaghi, Steve S. Cho, Shuting S. Cai, Emma De Ravin, Yash Singh, Joann Miller, Saad
Sheikh, Edward Delikatny, Zhiliang Cheng,
Theresa M. Busch, Jay F. Dorsey, Sunil Singhal, Andrew Tsourkas
& John Y. K. Lee. Combined
fluorescence-guided surgery and photodynamic therapy for glioblastoma
multiforme using cyanine and chlorin nanocluster. Journal of
Neuro-Oncology, 2020, 149, 243-252. (Abstract).
Sonia Kartha, Lesan
Yan, Meagan E. Ita, Ahmad Amirshaghaghi, Lijun Luo, Yulong Wei, Andrew Tsourkas, Beth
A. Winkelstein, and Zhiliang Cheng.* Phospholipase A2 Inhibitor-Loaded Phospholipid Micelles
Abolish Neuropathic Pain, ACS Nano,
2020, 14, 8103. (Abstract)
, , ,
, , , * and Indocyanine
Green-Coated Polycaprolactone Micelles for Fluorescence Imaging of Tumors,
ACS Applied Bio Materials, 2020, 3, 2344. (Abstract)
Jessica F. Liu,
Ziyang Lan, Carolina Ferrari, Joel M. Stein, Elizabeth Higbee-Dempsey, Lesan Yan, Ahmad Amirshaghaghi,
Zhiliang Cheng, David Issadore,* Andrew Tsourkas.* Use of oppositely-polarized external
magnets to improve the accumulation and penetration of magnetic nanocarriers
into solid tumors, ACS Nano, 2020, 14, 142. (Abstract)
2019
Lesan Yan, Lijun Luo, Ahmad Amirshaghaghi,
Joann Miller, Cathy Meng, Tianyan You, Theresa M.
Busch, Andrew Tsourkas, Zhiliang Cheng.*
Dextran-Benzoporphyrin Derivative (BPD) Coated
Superparamagnetic Iron Oxide Nanoparticle (SPION) Micelles for T2-Weighted
Magnetic Resonance Imaging and Photodynamic Therapy, Bioconjugate Chemistry, 2019, 30,
2974. (Abstract)
Ahmad Amirshaghaghi, Lesan Yan, Joann
Miller, Yonathan Daniel, Joel M. Stein, Theresa M. Busch, Zhiliang Cheng, Andrew Tsourkas.* Chlorin
e6-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters as a Theranostic Agent for Dual-Mode Imaging and Photodynamic
Therapy, Scientific
Reports. 2019, 9, 2613. (Abstract)
Ying Wang, Kun Qi,
Shansheng Yu, Guangri Jia, Zhiliang
Cheng, Lirong Zheng, Qiong Wu, Qiaoliang Bao, Qingqing Wang, Jingxiang Zhao,* Xiaoqiang Cui,* Weitao Zheng. Revealing the Intrinsic Peroxidase-Like Catalytic Mechanism of
Heterogeneous Single-Atom Co–MoS2. Nano-Micro Letters,
2019, 11, 102. (Abstract)
Bo Shang, Xiaoqiang Cui,* Lin Jiao, Kun Qi, Yingwei
Wang, Jinchang Fan, Yuanyuan Yue, Haiyu
Wang, Qiaoliang Bao, Xiaofeng
Fan, Zhiliang Cheng, Shaojun Guo, and Weitao Zheng*. Lattice Mismatch Induced
Ultra-stable 1T-Phase MoS2-Pd/Au for Plasmon-Enhanced Hydrogen Evolution, Nano Letters. 2019, 19, 2758-2764. (Abstract)
2018
Yonghua
Zhang, Junjie Ai, Yanan Dong, Shiyu Zhang, Qiang
Gao*, Honglan Qi, Chengxiao
Zhang, Zhiliang Cheng*. Combining 3D
graphene-like screen-printed carbon electrode with methylene blue-loaded
liposomal nanoprobes for phospholipase A2 detection. Biosensors and Bioelectronics, 2018, 126, 255-260. (Abstract)
Ahmad
Amirshaghaghi, Burcin Altun, Kido New, Lesan Yan, Joel
M. Stein, Zhiliang Cheng, Andrew Tsourkas*. Site-Specific Labeling of Cyanine and Porphyrin
Dye-Stabilized Nanoemulsions with Affibodies for
Cellular Targeting. Journal of the
American Chemical Society, 2018, 140, 13550-13553. (Abstract)
Jessica
F. Liu, Nishant Neel, Phillip Dang, Max Lamb, Jaime McKenna, Lauren Rodgers,
Brian Litt, Zhiliang Cheng, Andrew Tsourkas*, David Issadore*. Radiofrequency-Triggered
Drug Release from Nanoliposomes with Millimeter-Scale Resolution Using a
Superimposed Static Gating Field. Small,
2018, 14, 1802563. (Abstract)
Lesan Yan, Ahmad Amirshaghaghi,
Dennis Huang, Joann Miller, Joel M. Stein, Theresa M. Busch, Zhiliang Cheng*, Andrew Tsourkas*. Protoporphyrin IX (PpIX)
Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters for
Magnetic Resonance Imaging and Photodynamic Therapy. Advanced Functional Materials. 2018, 28, 1707030. (Abstract)
Bo
Shang, Pengfei Ma, Jinchang
Fan, Lin Jiao, Zijian Liu, Zheyu Zhang, Nuo Chen, Zhiliang Cheng, Xiaoqiang
Cui*, Weitao Zheng*. Stabilized monolayer 1T MoS2 embedded in CoOOH for highly efficient overall water splitting. Nanoscale, 2018, 10, 12330-12336. (Abstract)
2017
Sonia
Kartha, Lesan Yan,
Christine L. Weisshaar, Meagan E. Ita, Vladimir V. Shuvaev, Vladimir R. Muzykantov,
Andrew Tsourkas, Beth A. Winkelstein,* and Zhiliang Cheng*. Superoxide
Dismutase-Loaded Porous Polymersomes as Highly
Efficient Antioxidants for Treating Neuropathic Pain. Advanced Healthcare Materials. 2017, 6, 1700500. (Abstract)
Lesan Yan, Joann Miller, Min Yuan, Jessica F. Liu,
Theresa M. Busch, Andrew Tsourkas, and Zhiliang Cheng*. Improved Photodynamic
Therapy Efficacy of Protoporphyrin IX-Loaded Polymeric Micelles Using Erlotinib
Pretreatment. Biomacromolecules,
2017, 18 (6), 1836-1844. (Abstract)
2016
Di
Li, Weiguo Xu, Pengqiang
Li, Jianxun Ding*, Zhiliang Cheng, Li Chen, Lesan Yan*, and Xuesi Chen. Self-Targeted Polysaccharide Prodrug Suppresses
Orthotopic Hepatoma. Molecular
Pharmaceutics, 2016, 13 (12), 4231-4235. (Abstract)
Junling Li, Yonghua Zhang, Junjie Ai, Qiang Gao*, Honglan Qi, Chengxiao Zhang, Zhiliang Cheng*. Quantum dot cluster
(QDC)-loaded phospholipid micelles as FRET probe for phospholipase A2
detection. RSC Advances. 2016 Jan
1;6(19):15895-15899. (Abstract)
Jingzhuan Wan, Junjie Ai, Yonghua Zhang, Xiaohui
Geng, Qiang Gao*, Zhiliang Cheng*.
Signal-off impedimetric immunosensor for detection of Escherichia coli O157:H7.
Scientific Reports. 2016; 6:19806. (Abstract)
2015
Lesan Yan, Elizabeth Higbee, Andrew Tsourkas,
Zhiliang Cheng*. A simple method for
the synthesis polymeric vesicles and their application as MR contrast agent. Journal of Materials Chemistry B. 2015,
3, 9277-9284. (Abstract)
Guilong Zhang, Shiyao Lu, Junchao Qian, Kai Zhong, Jianming
Yao, Dongqing Cai,* Zhiliang Cheng* and Zhengyan
Wu*. Magnetic relaxation switch detecting boric acid or borate ester through
one-pot synehesized polyvinyl alcohol functionalized
nanomagnetic iron oxide. ACS Applied
Materials & Interfaces, 2015, 7 (30), 16837-16841. (Abstract)
Qiang
Gao, Lesan Yan, Michael Chiorazzo,
Jim Delikatny, Andrew Tsourkas
and Zhiliang Cheng*. PLA2-responsive
and SPIO-loaded phospholipid micelles. Chemical
Communications, 2015, 51, 12313-12315. (Abstract)
Lesan Yan, Samuel H. Crayton, Jayesh P. Thawani, Ahmad Amirshaghaghi,
Andrew Tsourkas, and Zhiliang Cheng*. A pH-responsive drug delivery platform based on
glycol chitosan-coated liposomes. Small,
2015, 11(37), 4870-4874. (Abstract)
McQuade
C, Al Zaki A, Desai Y, Vido M, Sakhuja T, Cheng Z,
Hickey RJ, Joh D, Park SJ, Kao G, Dorsey JF, Tsourkas
A. A Multifunctional Nanoplatform for Imaging, Radiotherapy, and the Prediction
of Therapeutic Response. Small.
2015,11(7), 834-843. (Abstract)
Shayanne A. Lajud, Danish A. Nagda, Peter Qiao, Nobuaki Tanaka, Alyssa Civantos, Rende Gu, Zhiliang
Cheng, Andrew Tsourkas, Bert W. Oalley Jr, Daqing Li. A Novel Chitosan-Hydrogel-Based
Nanoparticle Delivery System for Local Inner Ear Application. Otology & Neurotology, 2015, 36(2)
341-347. (Abstract)
2014
Zhiliang Cheng*, Andrew Tsourkas.
Monitoring Phospholipase A2 Activity with Gd-encapsulated Phospholipid
Liposomes. Scientific Reports. doi: 10.1038/srep06958. (Abstract)
Zhiliang Cheng,* Ajlan Al Zaki, Ian W
Jones, Henry K Hall, Craig A Aspinwall, Andrew Tsourkas.
Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly
efficient MRI contrast agent. Chemical
Communications, 2014, 50(19), 2502-2504. (Abstract)
James
Zhe Hui, Ajlan Al Zaki, Zhiliang Cheng, Vladimir Popik, Hongtao Zhang, Eline T. LuningPrak,
Andrew Tsourkas. Facile Method for the Site-Specific,
Covalent Attachment of Full-LengthIgG onto
Nanoparticles. Small, 2014, 10(16):
3354-3363. (Abstract)
Ajlan Al Zaki, Daniel Joh, Zhiliang Cheng, Andr Lus Branco De Barros, Gary Kao, Jay Dorsey,
and Andrew Tsourkas. Gold-Loaded Polymeric Micelles
for Computed Tomography-Guided Radiation Therapy Treatment and Radiosensitization. ACS
Nano, 2014, 8(1), 104-112. (Abstract)
2012
Zhiliang Cheng, Ajlan Al-Zaki, James Z
Hui, Vladimir R. Muzykantov, Andrew Tsourkas. Multifunctional Nanoparticles: Evaluating the
cost versus benefit of adding targeting and imaging capabilities. Science 2012, 338(6109):903-910. (Abstract)
Thusitha P. Muhandiramlage, Zhiliang Cheng, David L. Roberts, John
P. Keogh, Henry K. Hall, Jr. and Craig A. Aspinwall. Determination of pore
sizes and relative porosity in porous nanoshellarchitectures
using dextran retention with single monomer resolution and proton permeation. Analytical Chemistry 2012,
84(22):9754-9761. (Abstract)
Zhiliang Cheng, Ajlan Al-Zaki, James Z
Hui, Andrew Tsourkas. Simultaneous quantification of
tumor uptake for targeted and nontargeted liposomes and their encapsulated
contents by ICPMS. Analytical Chemistry.
2012,84(17):7578-7582. (Abstract)
Sameul H Crayton, Andrew Elias, Ajlan
Al-Zaki, Zhiliang Cheng, Andrew Tsourkas. ICP-MS analysis of Lanthanide-doped nanoparticles
as a non-radiative, multiplex approach to quantifybiodistribution
and blood clearance. Biomaterials
2012, 33(5):1509-1519. (Abstract)
2011
Zhiliang Cheng, Drew R Elias, Neha P Kamat,
Eric D Johnston, Andrei Poloukhtine, Vladimir Popik, Daniel A Hammer, Andrew Tsourkas.
Improved tumor targeting of polymer-based nanovesicles using polymer-lipid
blends. Bioconjugate Chemistry 2011,
22(10):2021-2029. (Abstract)
2010
Zhiliang Cheng, Antony K Chen, Ha-Young Lee, Andrew Tsourkas. Examination of folate-targeted liposomes with
encapsulated poly(2-propylacrylic acid) as a
pH-responsive nanoplatform for cytosolic drug delivery. Small 2010, 6(13):1398-1401. (Abstract)
Zhiliang Cheng, Daniel L J Thorek,
Andrew Tsourkas. Gd-conjugated dendrimer nanoclusters
as a tumor-targeted T1 magnetic resonance imaging contrast agent. Angewandte Chemie
International Edition 2010, 49(2):346-350. (Abstract)
Drew
R Elias, Zhiliang Cheng, Andrew Tsourkas. An intein-mediated
site-specific click conjugation strategy for improved tumor targeting of
nanoparticle systems. Small 2010,
6(21):2460-2468. (Abstract)
2009
Zhiliang Cheng, Daniel L J Thorek,
Andrew Tsourkas. Porous polymersomes
with encapsulated Gd-labeled dendrimers as highly efficient MRI contrast
agents. Advanced Functional Materials
2009,19(23):3753-3759. (Abstract)
2008
Zhiliang Cheng, Andrew Tsourkas.
Paramagnetic porous polymersomes, Langmuir, 2008,
24(15):8169-8173. PMID: 18570445 (Abstract)
Antony
K Chen, Zhiliang Cheng, Mark
A Behlke, Andrew Tsourkas. Assessing
the sensitivity of commercially available fluorophores to the
intracellular environment, Analytical
Chemistry, 2008, 80(19):7437-7444. (Abstract)
2006
Zhiliang Cheng, Gemma D D'Ambruoso,
Craig A Aspinwall, Stabilized porous phospholipid nanoshells,
Langmuir, 2006, 22, 9507-9511. (Abstract)
Zhiliang Cheng, Craig A Aspinwall, Nanometre-sized
molecular oxygen sensors prepared from polymer stabilized phospholipids
vesicles, Analyst, 2006, 131,
236-243. (Abstract)
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