Chemical Genomics/Organism HTSModel organisms such as C. elegans, drosophila, and zebrafish have helped define the underpinnings of modern biology with critical impact in neurology, stem cells, embryo development, morphogenesis, multi-organ physiology and toxicology, lifespan control and ageing. Organism-based chemical genomics allows unbiased genome wide exploration of target space. While the human genome is fully available, only half of human genes have any report whatsoever in the literature, and fewer than 2000 have five or more papers associated with them. This means that over half the target space for chemical discovery is largely untapped. Through the use of model organisms, the vision of the PCMD is to leverage organism-based, genome-wide research to bring new targets for chemical HTS. Special emphasis is placed on organism-based platforms that are HTS compatible. Central to this vision is the rapid translation of discovery in model organisms to mammalian HTS/probe production.
|
