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  Chemical Genomics/Organism HTS
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Director
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NIH Molecular Libraries and Imaging
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NIH Small Molecule Repository
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Publications
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Pubchem
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News Archive
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Top 200 Brand Name Drugs
(compiled by the Njarðarson Group at the University of Arizona)
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The Penn Center for
Molecular Discovery

Institute for Medicine and Engineering
1024 Vagelos Research Laboratories
The University of Pennsylvania
Philadelphia, PA 19104

Tel 215-573-5702 (office)
Tel 215-573-5704 (lab)
Fax 215-573-7227

Email pcmd@seas.upenn.edu

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Welcome to the Penn Center for Molecular Discovery!

The Penn Center for Molecular Discovery  (PCMD), founded at the University of Pennsylvania, is a multi-disciplinary center that screens small molecules from around the world in search of new, potentially useful biologically effective agents. The Penn Center for Molecular Discovery is housed within the Institute for Medicine and Engineering.The Director of the Center is Scott Diamond, Ph.D., the Arthur E. Humphrey Professor of Chemical and Biomolecular Engineering. The PCMD contributes to a massive, public-domain database (PubChem) where interactions between the NIH repository and thousands of biological targets can be data-mined at an unprecedented level.

 

  Click on the image above to view a Windows Media video of our robot arm in action.

Completed High-Throughput Screens (HTS)

Cathepsin B

Factor XIa

Thrombin

Cathepsin S

Factor XIIa

Kallikrein

Cathepsin L

Zebrafish Lipid Metabolism

MDM2 E3 Ligase

Cathepsin G

Yeast Toxicity

Complement Alternative

Complement C1s

eIF2b

Rad51

RNA Polymerase

C. albicans

siRNA enhancers of lipofection

 

 

TB RmlC

CBIT Completed Screens

The Chemical Biology in Translation (CBIT) is directed by Dr. Scott Diamond and Dr. William DeGrado and provides resources in assay development, high throughput screening, hit confirmation, mechanism-of-action studies, docking, and medicinal chemistry expansion of prioritized scaffolds. Request for Proposals (RFP) are broadly advertised each year to the biological research community for chemical biology targets suitable for HTS and chemistry optimization.

Malaria Life Cycle

IP/TP dimer signaling

Chondrogenesis

  

c-myb

Osteogenesis

Fog-Nurd

  

Utrophin

 

 

  

Request For Applications:

RFA-RM-06-003 Pilot-Scale Libraries (PSL) for High-Throughput Screening (P41). Letter of Intent: Sept. 4, 2009; Application Due: Oct. 1, 2009; $250K directs/year for 3 years.

NIH Announces Funding for Assay Development for HTS (R21)

Grants of $100,000 for one year are available for the development of assays in collaboration with the PCMD. Assay projects that are successfully developed in this Program will be eligible to directly enter the Molecular Libraries Probe Production Centers Network (http://mli.nih.gov/mli/mlpcn/).

RFP: Assay Development for High Throughput Molecular Screening (R21)
Notice of Fast Track Eligibility

About The Penn Center for Molecular Discovery (PCMD)

 

Instrumentation / Laboratory

High Throughput Screening (HTS)

Microarray Screening

 

 

Protease Proteomics

Zebra Fish Screening

Synthetic Chemistry

 

Metallo-Organic Pharmacophores

Cheminformatics and Computational Chemistry

Chemical Genomics/ Organism HTS

 

 

 
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